Apparently there could be. Herewith the opening of an article just out in Nature magazine:
In 2016, pharmacologist Susan Howlett wrote up a study on how hormone levels during pregnancy affect heart function and sent it off to a journal. When the reviewers’ comments came back, two of the three had asked an unexpected question: where were the tissues from male mice?
Because they were studying high hormone levels related to pregnancy, Howlett, at Dalhousie University in Halifax, Canada, and her team had used only female animals. “I was really surprised that they wanted us to repeat everything in males,” she said.
Nonetheless, they obliged, and their findings were published in 2017. As expected, they found no effect of the hormone progesterone on heart function in males; in females, it influenced the activity of cardiac cells.
Howlett had mixed feelings about the request to add males. “It was a big ask and it was a lot more research.” But in general, she adds, it’s really important to factor sex into studies. “I’m a big proponent of doing experiments in both males and females.”
How long will it take “the scienceTM” to acknowledge transgender mice, who can get pregnant just as readily as human transgender men? How about we just move right away to micex and save everyone a whole lot of trouble?